mandag den 4. marts 2013

Exercise and...TRPA1 and TRPV1

I do find some weird information when looking for information on exercise...

"Exercise-induced anaphylaxis (EIA) is a rare disorder in which anaphylaxis occurs after physical activity. The symptoms may include pruritus, hives, flushing, wheezing, and GI involvement, including nausea, abdominal cramping, and diarrhea. If physical activity continues, patients may progress to more severe symptoms, including angioedema, laryngeal edema, hypotension, and, ultimately, cardiovascular collapse." Reference

A disease where you get sick of exercise...that reminds me of something....

But what mechanisms are involved in this disease? You will not believe it - once again TRPA1:

"This review mainly focuses on TRPV1 and TRPA1 and the role they have in the allergic response and how these receptors may be influenced in exercise-induced anaphylaxis.":
Transient receptor potentials (TRPs) and anaphylaxis

From the article:
Exercise-induced anapylaxis is likely to involve both TRPV1 and TRPA1 ion channels. Exercise is an oxidative state, with the individual consuming more oxygen and generating  a range of compounds including superoxide anions, hydoxyl radicals, and hydrogen perioxide. TRPA1 is the main oxidant receptor and the ion channel activates on sensing these irritant compounds. Importantly, it acts as a direct sensor of oxygen and is activated during hypoxia. Serotonin and bradykinin also increase with exercise influencing priming of TRPV1.

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