A role for TRPs in ME/CFS/POTS/MCS/pain/endothelial dysfunction... ? Can some of the symptoms be explained, if we understand the TRPs?
TRP Ion Channels – especially TRPA1 references:
Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) [1]
Multiple Chemical Sensitivity (MCS), asthma and airways [12] , [13] , [14] , [15] , [16] , [17], [18] , [19] , [20] , [21], [22] , [23]
Irritable Bowel Syndrome (IBS) and gastrointestinal tract [24], [25] , [26] , [27] , [28] , [29] , [30] , [31], [32] , [33]
Reflux [34] , [35]
Pain – inflammation – central sensitization - neuropathy [36], [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46], [47] , [48] , [49] , [50], [51], [52], [53] , [54] , [55], [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64], [65]
LPS – bacterial endotoxin [66]
Endothelial function/dysfunction [67], [68] , [69] , [70] , [71] ,[72] , [73]
Vascular function [74] , [75] , [76] , [77] , [78] , [79] ,[80] , [81] , [82]
Regulation af cerebral blood flow [83] ,[84] , [85]
Migraine [86], [87] , [88] , [89] , [90]
Exercise [91] , [92] , [93] , [94] , [95]
Stress [96] , [97] , [98]
Hypoxia, sensors of oxygen [99] , [100] , [101] , [102] , [103] ,[104]
Mitochondria, redox, ROS, RNS [105] , [106] , [107] , [108], [109] , [110] , [111]
Glial cells[112]
Dorsal root ganglion [113] , [114]
Vagus nerve [115]
Spinal Cord Injury (SCI) [116]
Bladder pain syndrome/ bladder dysfunction [117], [118], [119] , [120] , [121] , [122] , [123]
Rosacea [124]
Analgesia [125], [126], [127] , [128] , [129] , [130]
TRP in disease [131], [132]
TRP in sensory transduction and cellular signaling [133], [134] , [135]
TRP projects [136] , [137] ,
TRP patent applications [138] , [139] , [140], [141] , [142]
Treatment [143] , [144]
Inhibition of TRPA1 [145]
[2] Evidence for the pathophysiological relevance of TRPA1 receptors in the cardiovascular system in vivo
[3] TRPA1 channels in the vasculature
[4] Transient receptor potential channels and vascular function
[5] Transient receptor potential (TRP) channels, vascular tone and autoregulation of cerebral blood flow
[6] Endothelium-dependent cerebral artery dilation mediated by TRPA1 and Ca2+-Activated K+ channels
[7] TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation
[8] TRPA1 is involved in mediating vasodilation. TRPA1 can also influence changes in blood pressure of possible relevance to autonomic system reflexes and potentially to vasovagal/neurocardiogenic syncope disorders
[9] Involvement of TRPA1 receptors in meningeal blood flow induced by formation of nitroxyl (NO-/HNO)
[10] Redox Regulation of Endothelial Canonical Transient Receptor Potential Channels
[11] TRPA1 channels play a critical role in cold-induced vasodilatation
[12] Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control
[13] Activation of Transient Receptor Potential Ankyrin-1 (TRPA1) in Lung Cells by Wood Smoke Particulate Material
[14] Pre-clinical studies in cough research: Role of Transient Receptor Potential (TRP) channels
[15] Epithelial Cell TRPV1-Mediated Airway Sensitivity as a Mechanism for Respiratory Symptoms Associated with Gulf War Illness
[16] Transient Receptor Potential Channels Encode Volatile Chemicals Sensed by Rat Trigeminal Ganglion Neurons
[17] TRPA1 detects environmental chemicals and induces avoidance behavior and arousal from sleep
[18] Crucial Role of Transient Receptor Potential Ankyrin 1 and Mast Cells in Induction of Nonallergic Airway Hyperreactivity in Mice
[19] Transient receptor potential channels and occupational exposure
[20] Functional expression of the transient receptor potential channel TRPA1, a sensor for toxic lung inhalants, in pulmonary epithelial cells
[21] Pre-clinical studies in cough research: role of Transient Receptor Potential (TRP) channels
[22] A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma
[23] Multiple types of sensory neurons respond to irritating volatile organic compounds (VOCs): calcium fluorimetry of trigeminal ganglion neurons
[24] Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain
[25] Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain.
[26] QGP-1 cells release 5-HT via TRPA1 activation; a model of human enterochromaffin cells
[27] TRPA1 agonists delay gastric emptying in rats through serotonergic pathways
[28] TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells
[29] Psychological Co-morbidity in Functional Gastrointestinal Disorders: Epidemiology, Mechanisms and Management
[30] Sensory neuro-immune interactions differ between irritable bowel syndrome subtypes
[31] Acute Uterine Irritation Provokes Colonic Motility via Transient Receptor Potential A1-dependent Spinal NR2B Phosphorylation in Rats
[32] Identification of enteroendocrine cells that express TRPA1 channels in the mouse intestine
[33] Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain
[34] Airway Reflux, Cough and Respiratory Disease
[35] Inflammation and Oxidative Stress in Gastroesophageal Reflux Disease
[36] Two to tango: GPCR oligomers and GPCR-TRP channel interactions in nociception.
[37] Role of Oxidative Stress and Ca(2+) Signaling on Molecular Pathways of Neuropathic Pain in Diabetes: Focus on TRP Channels.
[38] TRPA1 Mediates Mechanical Sensitization in Nociceptors during Inflammation
[39] Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control
[40] Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) Coupling is Required for Sustained Inflammatory Signaling
[41] Chemokines as Pain Mediators and Modulators
[42] Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy
[43] The dynamic TRPA1 channel: a suitable pharmacological pain target?
[44] Sustained TRPA1 activation in vivo
[45] Reactive oxygen species enhance excitatory synaptic transmission in rat spinal dorsal horn neurons by activating TRPA1 and TRPV1 channels
[46] TRPA1: A Transducer and Amplifier of Pain and Inflammation
[47] Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling
[48] Reactive oxygen species enhance excitatory synaptic transmission in rat spinal dorsal horn neurons by activating TRPA1 and TRPV1 channels
[49] Acrolein involvement in sensory and behavioral hypersensitivity following spinal cord injury in the rat
[50] Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Cav3.2 and TRPA1 channels in mice
[51] Sustained firing of TRPA1 elicited by reactive agonists
[52] Transient receptor potential A1 increase glutamate release on brain stem neurons
[53] TRPV1 and TRPA1 Mediate Peripheral Nitric Oxide-Induced Nociception in Mice
[54] Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors
[55] Sustained firing of TRPA1 elicited by reactive agonists
[56] Behavioral and Electrophysiological Study of Thermal and Mechanical Pain Modulation by TRP Channel Agonists
[57] Cortical spreading depression induces oxidative stress in the trigeminal nociceptive system
[58] Hypoxia-inducible Factor-1α (HIF1α) Switches on Transient Receptor Potential Ankyrin Repeat 1 (TRPA1) Gene Expression via a Hypoxia Response Element-like Motif to Modulate Cytokine Release
[59] Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation
[60] NGF up-regulates TRPA1: implications for orofacial pain
[61] Differential methylation of the TRPA1 promoter in pain sensitivity
[62] Neurotrophins, endocannabinoids and thermo-transient receptor potential: a threesome in pain signalling
[63] Modulation of Transient Receptor Vanilloid 1 Activity by Transient Receptor Potential
Ankyrin 1
[64] TRP-channels as key integrators of lipid pathways in nociceptive neurons
[65] Methylglyoxal Evokes Pain by Stimulating TRPA1
[66] TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins
[67] TRP channels in endothelial function and dysfunction
[68] Expression and modulation of TRP channels in human microvascular endothelial cells
[69] Regulation and Function of TRPM7 in Human Endothelial Cells: TRPM7 as a Potential Novel Regulator of Endothelial Function
[70] Endothelium-dependent cerebral artery dilation mediated by transient receptor potential and Ca2+-activated K+ channels
[71] TRP channel Ca2+ sparklets: fundamental signals underlying endothelium-dependent hyperpolarization
[72] Model for TRPC5-mediated feedback of Ca2+ and NO signaling in endothelial cells and attenuation of Ca2+ entry through TRPC6 by NO in smooth muscle cells
[73] Cooperative Interaction of trp Melastatin Channel Transient Receptor Potential (TRPM2) With Its Splice Variant TRPM2 Short Variant Is Essential for Endothelial Cell Apoptosis
[74] Transient receptor potential channels and vascular function
[75] TRPA1 channels in the vasculature
[76] TRPV channels and vascular function
[77] TRP channels in vascular endothelial cells
[78] Evidence for the pathophysiological relevance of TRPA1 receptors in the cardiovascular system in vivo
[79] TRP channel and cardiovascular disease
[80] Transient Receptor Potential Channels in Cardiovascular Function and Disease
[81] Emerging concepts for the role of TRP channels in the cardiovascular system
[82] The NO/ONOO-cycle as the central cause of heart failure
[83] Endogenously-Generated Lipid Peroxidation Products Dilate Rat Cerebral Arteries by Activating TRPA1 Channels in the Endothelium
[84] TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNELS, VASCULARTONE AND AUTOREGULATION OF CEREBRAL BLOOD FLOW
[85] Proposed Signaling Pathway for TRPA1-Mediated Vasodilation of Cerebral Arteries
[86] TRPA1 and other TRP channels in migraine
[87] Activation of TRPA1 on dural afferents: a potential mechanism of headache pain
[88] Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel
[89] Cortical spreading depression induces oxidative stress in the trigeminal nociceptive system
[90] The TRPA1 Channel in Migraine Mechanism and Treatment
[91] Transient receptor potentials (TRPs) and anaphylaxis
[92] Muscle Afferent Receptors Engaged in Augmented Sympathetic Responsiveness in Peripheral Artery Disease
[93] Transient receptor potential A1 channel contributes to activation of the muscle reflex
[94] Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects
[95] Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls
[96] TRPV1 is a stress response protein in the central nervous system.
[97] Importance of TRP channels in pain: implications for stress
[98] Table 1. Cross-talk between several stress-related factors and TRP channels
[99] TRPA1 underlies a sensing mechanism for O2
[100] Reference: Channels: A TR(i)P in the air
[101] Reference: TRP channels: sensors and transducers of gasotransmitter signals
[102] Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release
[103] Hypersensitivity of lung vagal C fibers induced by acute intermittent hypoxia in rats: role of reactive oxygen species and TRPA1
[104] TRP channels as sensors of oxygen availability
[105] Sensory Nerve Terminal Mitochondrial Dysfunction Activates Airway Sensory Nerves Via Transient Receptor Potential (TRP) Channels
[106] Role of Reactive Oxygen Species and Redox in Regulating the Function of Transient Receptor Potential Channels
[107] Sensory Nerve Terminal Mitochondrial Dysfunction Activates Airway Sensory Nerves Via Transient Receptor Potential (TRP) Channels
[108] Redox Regulation of Transient Receptor Potential Channels
[109] Transnitrosylation Directs TRPA1 Selectivity in N-Nitrosamine Activators
[110] Emerging roles of TRPA1 in sensation of oxidative stress and its implications in defense anddanger
[111] Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress
[112] Pathophysiological roles of transient receptor potential channels in glial cells.
[113] Systematic and quantitative mRNA expression analysis of TRP channel genes at the single trigeminal and dorsal root ganglion level in mouse
[114] Reactive oxygen species enhance excitatory synaptic transmission in rat spinal dorsal horn neurons by activating TRPA1 and TRPV1 channels
[115] TRPV1, TRPA1, and CB1 in the isolated vagus nerve--axonal chemosensitivity and control of neuropeptide release
[116] Acrolein involvement in sensory and behavioral hypersensitivity following spinal cord injury in the rat
[117] Transient receptor potential A1 receptor-mediated neural cross-talk and afferent sensitization induced by oxidative stress: Implication for the pathogenesis of interstitial cystitis/bladder pain syndrome.
[118] Mechanisms of Disease: involvement of the urothelium in bladder dysfunction
[119] THE ROLE OF TRPA1 CHANNELS IN ACTIVATION OF SINGLE UNIT MECHANOSENSITIVE BLADDER AFFERENT ACTIVITIES IN THE RAT
[120] TRPA1 receptor modulation attenuates bladder overactivity induced by spinal cord injury
[121] Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder
[122] Antagonism of the transient receptor potential ankyrin 1 (TRPA1) attenuates hyperalgesia andurinary bladder overactivity in cyclophosphamide-induced haemorrhagic cystitis
[123] Transient receptor potential channels in bladder function
[124] Neurovascular Aspects of Skin Neurogenic Inflammation
[125] TRPA1 as an Analgesic Target
[126] Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors
[127] Targeting TRP channels for pain relief
[128] TRP channels and analgesia
[129] Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as Emerging Target for Novel Analgesics and Anti-Inflammatory Agents
[130] SuperPain—a resource on pain-relieving compounds targeting ion channels
[131] Transient receptor potential cation channels in disease.
[132] DYSREGULATED MRNAS MAY ALSO EXPLAIN COMMON CO-MORBIDITIES OF CFS
[133] TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades.
[134] Chapter 11 TRPA1 : A Sensory Channel of Many Talents
[135] The molecular basis for species-specific activation of human TRPA1 by protons involves poorly conserved residues within transmembrane domains 5 and 6
[136] ROLE OF TRP CHANNELS IN ENVIRONMENTAL IRRITANT-INDUCED HEADACHE DESCRIPTION
[137] POST-EXERCISE ION CHANNEL GENE EXPRESSION BIOMARKERS IN CFS
[138] NOVEL TRPA1 ANTAGONISTS
[139] Treatment of Respiratory Disorders using TRPA1 Antagonists
[140] PHARMACEUTICAL COMPOSITION COMPRISING A TRPA1 ANTAGONIST AND AN ANTICHOLINERGIC AGENT
[141] Heterocyclic amides as modulators of TRPA1
[142] Compounds useful for treating disorders related to TRPA1
[143] Modulation of TRP channels by resveratrol and other stilbenoids
[144] USE OF TRPA1 RECEPTOR ANTAGONISTS FOR TREATING DISEASES ASSOCIATED WITH BACTERIAL INFECTIONS
[145] Superpain database
TRP Ion Channels – especially TRPA1 references:
Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) [1]
Postural Orthostatic Tachycardia Syndrome (POTS) and vascular function [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9], [10], [11]
Multiple Chemical Sensitivity (MCS), asthma and airways [12] , [13] , [14] , [15] , [16] , [17], [18] , [19] , [20] , [21], [22] , [23]
Irritable Bowel Syndrome (IBS) and gastrointestinal tract [24], [25] , [26] , [27] , [28] , [29] , [30] , [31], [32] , [33]
Reflux [34] , [35]
Pain – inflammation – central sensitization - neuropathy [36], [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46], [47] , [48] , [49] , [50], [51], [52], [53] , [54] , [55], [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64], [65]
LPS – bacterial endotoxin [66]
Endothelial function/dysfunction [67], [68] , [69] , [70] , [71] ,[72] , [73]
Vascular function [74] , [75] , [76] , [77] , [78] , [79] ,[80] , [81] , [82]
Regulation af cerebral blood flow [83] ,[84] , [85]
Migraine [86], [87] , [88] , [89] , [90]
Exercise [91] , [92] , [93] , [94] , [95]
Stress [96] , [97] , [98]
Hypoxia, sensors of oxygen [99] , [100] , [101] , [102] , [103] ,[104]
Mitochondria, redox, ROS, RNS [105] , [106] , [107] , [108], [109] , [110] , [111]
Glial cells[112]
Dorsal root ganglion [113] , [114]
Vagus nerve [115]
Spinal Cord Injury (SCI) [116]
Bladder pain syndrome/ bladder dysfunction [117], [118], [119] , [120] , [121] , [122] , [123]
Rosacea [124]
Analgesia [125], [126], [127] , [128] , [129] , [130]
TRP in disease [131], [132]
TRP in sensory transduction and cellular signaling [133], [134] , [135]
TRP projects [136] , [137] ,
TRP patent applications [138] , [139] , [140], [141] , [142]
Treatment [143] , [144]
Inhibition of TRPA1 [145]
References:
[1] Translation from Mouse Sensory Neurons to Fibromyalgia and Chronic Fatigue Syndromes.[2] Evidence for the pathophysiological relevance of TRPA1 receptors in the cardiovascular system in vivo
[3] TRPA1 channels in the vasculature
[4] Transient receptor potential channels and vascular function
[5] Transient receptor potential (TRP) channels, vascular tone and autoregulation of cerebral blood flow
[6] Endothelium-dependent cerebral artery dilation mediated by TRPA1 and Ca2+-Activated K+ channels
[7] TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation
[8] TRPA1 is involved in mediating vasodilation. TRPA1 can also influence changes in blood pressure of possible relevance to autonomic system reflexes and potentially to vasovagal/neurocardiogenic syncope disorders
[9] Involvement of TRPA1 receptors in meningeal blood flow induced by formation of nitroxyl (NO-/HNO)
[10] Redox Regulation of Endothelial Canonical Transient Receptor Potential Channels
[11] TRPA1 channels play a critical role in cold-induced vasodilatation
[12] Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control
[13] Activation of Transient Receptor Potential Ankyrin-1 (TRPA1) in Lung Cells by Wood Smoke Particulate Material
[14] Pre-clinical studies in cough research: Role of Transient Receptor Potential (TRP) channels
[15] Epithelial Cell TRPV1-Mediated Airway Sensitivity as a Mechanism for Respiratory Symptoms Associated with Gulf War Illness
[16] Transient Receptor Potential Channels Encode Volatile Chemicals Sensed by Rat Trigeminal Ganglion Neurons
[17] TRPA1 detects environmental chemicals and induces avoidance behavior and arousal from sleep
[18] Crucial Role of Transient Receptor Potential Ankyrin 1 and Mast Cells in Induction of Nonallergic Airway Hyperreactivity in Mice
[19] Transient receptor potential channels and occupational exposure
[20] Functional expression of the transient receptor potential channel TRPA1, a sensor for toxic lung inhalants, in pulmonary epithelial cells
[21] Pre-clinical studies in cough research: role of Transient Receptor Potential (TRP) channels
[22] A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma
[23] Multiple types of sensory neurons respond to irritating volatile organic compounds (VOCs): calcium fluorimetry of trigeminal ganglion neurons
[24] Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain
[25] Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain.
[26] QGP-1 cells release 5-HT via TRPA1 activation; a model of human enterochromaffin cells
[27] TRPA1 agonists delay gastric emptying in rats through serotonergic pathways
[28] TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells
[29] Psychological Co-morbidity in Functional Gastrointestinal Disorders: Epidemiology, Mechanisms and Management
[30] Sensory neuro-immune interactions differ between irritable bowel syndrome subtypes
[31] Acute Uterine Irritation Provokes Colonic Motility via Transient Receptor Potential A1-dependent Spinal NR2B Phosphorylation in Rats
[32] Identification of enteroendocrine cells that express TRPA1 channels in the mouse intestine
[33] Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain
[34] Airway Reflux, Cough and Respiratory Disease
[35] Inflammation and Oxidative Stress in Gastroesophageal Reflux Disease
[36] Two to tango: GPCR oligomers and GPCR-TRP channel interactions in nociception.
[37] Role of Oxidative Stress and Ca(2+) Signaling on Molecular Pathways of Neuropathic Pain in Diabetes: Focus on TRP Channels.
[38] TRPA1 Mediates Mechanical Sensitization in Nociceptors during Inflammation
[39] Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control
[40] Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) Coupling is Required for Sustained Inflammatory Signaling
[41] Chemokines as Pain Mediators and Modulators
[42] Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy
[43] The dynamic TRPA1 channel: a suitable pharmacological pain target?
[44] Sustained TRPA1 activation in vivo
[45] Reactive oxygen species enhance excitatory synaptic transmission in rat spinal dorsal horn neurons by activating TRPA1 and TRPV1 channels
[46] TRPA1: A Transducer and Amplifier of Pain and Inflammation
[47] Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling
[48] Reactive oxygen species enhance excitatory synaptic transmission in rat spinal dorsal horn neurons by activating TRPA1 and TRPV1 channels
[49] Acrolein involvement in sensory and behavioral hypersensitivity following spinal cord injury in the rat
[50] Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Cav3.2 and TRPA1 channels in mice
[51] Sustained firing of TRPA1 elicited by reactive agonists
[52] Transient receptor potential A1 increase glutamate release on brain stem neurons
[53] TRPV1 and TRPA1 Mediate Peripheral Nitric Oxide-Induced Nociception in Mice
[54] Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors
[55] Sustained firing of TRPA1 elicited by reactive agonists
[56] Behavioral and Electrophysiological Study of Thermal and Mechanical Pain Modulation by TRP Channel Agonists
[57] Cortical spreading depression induces oxidative stress in the trigeminal nociceptive system
[58] Hypoxia-inducible Factor-1α (HIF1α) Switches on Transient Receptor Potential Ankyrin Repeat 1 (TRPA1) Gene Expression via a Hypoxia Response Element-like Motif to Modulate Cytokine Release
[59] Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation
[60] NGF up-regulates TRPA1: implications for orofacial pain
[61] Differential methylation of the TRPA1 promoter in pain sensitivity
[62] Neurotrophins, endocannabinoids and thermo-transient receptor potential: a threesome in pain signalling
[63] Modulation of Transient Receptor Vanilloid 1 Activity by Transient Receptor Potential
Ankyrin 1
[64] TRP-channels as key integrators of lipid pathways in nociceptive neurons
[65] Methylglyoxal Evokes Pain by Stimulating TRPA1
[66] TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins
[67] TRP channels in endothelial function and dysfunction
[68] Expression and modulation of TRP channels in human microvascular endothelial cells
[69] Regulation and Function of TRPM7 in Human Endothelial Cells: TRPM7 as a Potential Novel Regulator of Endothelial Function
[70] Endothelium-dependent cerebral artery dilation mediated by transient receptor potential and Ca2+-activated K+ channels
[71] TRP channel Ca2+ sparklets: fundamental signals underlying endothelium-dependent hyperpolarization
[72] Model for TRPC5-mediated feedback of Ca2+ and NO signaling in endothelial cells and attenuation of Ca2+ entry through TRPC6 by NO in smooth muscle cells
[73] Cooperative Interaction of trp Melastatin Channel Transient Receptor Potential (TRPM2) With Its Splice Variant TRPM2 Short Variant Is Essential for Endothelial Cell Apoptosis
[74] Transient receptor potential channels and vascular function
[75] TRPA1 channels in the vasculature
[76] TRPV channels and vascular function
[77] TRP channels in vascular endothelial cells
[78] Evidence for the pathophysiological relevance of TRPA1 receptors in the cardiovascular system in vivo
[79] TRP channel and cardiovascular disease
[80] Transient Receptor Potential Channels in Cardiovascular Function and Disease
[81] Emerging concepts for the role of TRP channels in the cardiovascular system
[82] The NO/ONOO-cycle as the central cause of heart failure
[83] Endogenously-Generated Lipid Peroxidation Products Dilate Rat Cerebral Arteries by Activating TRPA1 Channels in the Endothelium
[84] TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNELS, VASCULARTONE AND AUTOREGULATION OF CEREBRAL BLOOD FLOW
[85] Proposed Signaling Pathway for TRPA1-Mediated Vasodilation of Cerebral Arteries
[86] TRPA1 and other TRP channels in migraine
[87] Activation of TRPA1 on dural afferents: a potential mechanism of headache pain
[88] Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel
[89] Cortical spreading depression induces oxidative stress in the trigeminal nociceptive system
[90] The TRPA1 Channel in Migraine Mechanism and Treatment
[91] Transient receptor potentials (TRPs) and anaphylaxis
[92] Muscle Afferent Receptors Engaged in Augmented Sympathetic Responsiveness in Peripheral Artery Disease
[93] Transient receptor potential A1 channel contributes to activation of the muscle reflex
[94] Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects
[95] Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls
[96] TRPV1 is a stress response protein in the central nervous system.
[97] Importance of TRP channels in pain: implications for stress
[98] Table 1. Cross-talk between several stress-related factors and TRP channels
[99] TRPA1 underlies a sensing mechanism for O2
[100] Reference: Channels: A TR(i)P in the air
[101] Reference: TRP channels: sensors and transducers of gasotransmitter signals
[102] Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release
[103] Hypersensitivity of lung vagal C fibers induced by acute intermittent hypoxia in rats: role of reactive oxygen species and TRPA1
[104] TRP channels as sensors of oxygen availability
[105] Sensory Nerve Terminal Mitochondrial Dysfunction Activates Airway Sensory Nerves Via Transient Receptor Potential (TRP) Channels
[106] Role of Reactive Oxygen Species and Redox in Regulating the Function of Transient Receptor Potential Channels
[107] Sensory Nerve Terminal Mitochondrial Dysfunction Activates Airway Sensory Nerves Via Transient Receptor Potential (TRP) Channels
[108] Redox Regulation of Transient Receptor Potential Channels
[109] Transnitrosylation Directs TRPA1 Selectivity in N-Nitrosamine Activators
[110] Emerging roles of TRPA1 in sensation of oxidative stress and its implications in defense anddanger
[111] Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress
[112] Pathophysiological roles of transient receptor potential channels in glial cells.
[113] Systematic and quantitative mRNA expression analysis of TRP channel genes at the single trigeminal and dorsal root ganglion level in mouse
[114] Reactive oxygen species enhance excitatory synaptic transmission in rat spinal dorsal horn neurons by activating TRPA1 and TRPV1 channels
[115] TRPV1, TRPA1, and CB1 in the isolated vagus nerve--axonal chemosensitivity and control of neuropeptide release
[116] Acrolein involvement in sensory and behavioral hypersensitivity following spinal cord injury in the rat
[117] Transient receptor potential A1 receptor-mediated neural cross-talk and afferent sensitization induced by oxidative stress: Implication for the pathogenesis of interstitial cystitis/bladder pain syndrome.
[118] Mechanisms of Disease: involvement of the urothelium in bladder dysfunction
[119] THE ROLE OF TRPA1 CHANNELS IN ACTIVATION OF SINGLE UNIT MECHANOSENSITIVE BLADDER AFFERENT ACTIVITIES IN THE RAT
[120] TRPA1 receptor modulation attenuates bladder overactivity induced by spinal cord injury
[121] Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder
[122] Antagonism of the transient receptor potential ankyrin 1 (TRPA1) attenuates hyperalgesia andurinary bladder overactivity in cyclophosphamide-induced haemorrhagic cystitis
[123] Transient receptor potential channels in bladder function
[124] Neurovascular Aspects of Skin Neurogenic Inflammation
[125] TRPA1 as an Analgesic Target
[126] Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors
[127] Targeting TRP channels for pain relief
[128] TRP channels and analgesia
[129] Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as Emerging Target for Novel Analgesics and Anti-Inflammatory Agents
[130] SuperPain—a resource on pain-relieving compounds targeting ion channels
[131] Transient receptor potential cation channels in disease.
[132] DYSREGULATED MRNAS MAY ALSO EXPLAIN COMMON CO-MORBIDITIES OF CFS
[133] TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades.
[134] Chapter 11 TRPA1 : A Sensory Channel of Many Talents
[135] The molecular basis for species-specific activation of human TRPA1 by protons involves poorly conserved residues within transmembrane domains 5 and 6
[136] ROLE OF TRP CHANNELS IN ENVIRONMENTAL IRRITANT-INDUCED HEADACHE DESCRIPTION
[137] POST-EXERCISE ION CHANNEL GENE EXPRESSION BIOMARKERS IN CFS
[138] NOVEL TRPA1 ANTAGONISTS
[139] Treatment of Respiratory Disorders using TRPA1 Antagonists
[140] PHARMACEUTICAL COMPOSITION COMPRISING A TRPA1 ANTAGONIST AND AN ANTICHOLINERGIC AGENT
[141] Heterocyclic amides as modulators of TRPA1
[142] Compounds useful for treating disorders related to TRPA1
[143] Modulation of TRP channels by resveratrol and other stilbenoids
[144] USE OF TRPA1 RECEPTOR ANTAGONISTS FOR TREATING DISEASES ASSOCIATED WITH BACTERIAL INFECTIONS
[145] Superpain database
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