mandag den 10. februar 2014

Exercise followed by pain and exhaustion - is it ME?

Exercise, fasting and cold temperatures as triggers for pain episodes followed by exhaustion and deep sleep. The period of pain is accompanied by breathing difficulties, tachycardia and sweating. Is it Myalgic encephalomyelitis?

No, it is Gain-of-Function Mutation in TRPA1.

A point mutation in the S4 transmembrane segment of TRPA1, a key sensor for environmental
irritants, causes Familial Episodic Pain Syndrome. The mutant channel showed a normal pharmacological profile but altered biophysical properties, with a 5-fold increase in inward current on activation at normal resting potentials.

Check out the fine paper and video that explains the discovery:

A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome

More about TRPA1:

A role for TRPs in ME/CFS/POTS/MCS/pain/endothelial dysfunction...?

TRP blogposts - an overview

Ingen kommentarer:

Send en kommentar

Bemærk! Kun medlemmer af denne blog kan sende kommentarer.