lørdag den 22. februar 2014

Basic knowledge NO - H(2)S - CO interaction - where to begin.

If dysregulation of NO and H(2)S is involved in ME/CFS and POTS, I would like to get som basic knowledge about how these parameters interact. 

Where do you start, if you don't now anything?  I started here: Nitric Oxide: Biology and Chemistry 

The journal have recently emphasized the importance of understanding the interaction between NO, H(2)S and CO: Embracing sulfide and CO to understand nitric oxide biology

Quote from this paper: "The availability of NO is dependent on the relative rates of NO formation and trapping by oxygenated hemes, co-generated reactive oxygen species and perhaps H2S. Thus, the formation of secondary reactive nitrogen oxide species such as peroxynitrite (ONOO−), nitrogen dioxide (NO2), and dinitrogen trioxide (N2O3) all depends on the relative flux rates of generation of individual reactants, nearby antioxidant enzyme expression/activity, and even the presence of carbon dioxide/bicarbonate (CO2/HCO3−)."

Remember that availability of NO is discussed in ME.

And dysregulation of H(2)S in ME and POTS is also a subject

The paper mentioned above refers to this review: Chemical foundations of hydrogen sulfide biology:
  • This review includes the basic physical and chemical properties of H(2)S and H(2)S chemistry.
  • This review focuses on the chemical foundations of H(2)S biology and methodology.
  • This review introduces standard terminology to the H(2)S field.
  • This review calls attention to chemical misconceptions in the studies of H(2)S.

and to this paper Hydrogen sulfide chemical biology: Pathophysiological roles and detection:
  • H(2)S chemical biology and pathophysiology are rapidly evolving fields.
  • Accurate H(2)S detection is crucial for understanding its biological roles.
  • H(2)S interactions with gasotransmitters, e.g., NO, uniquely regulate tissue function.

Since gut dysfunction and the microbiome also are important issues in ME, this article also seems to be important: Microbial regulation of host hydrogen sulfide bioavailability and metabolism

  • H(2)S in its various biochemical forms differs significantly between tissues.
  • The microbiota affects H(2)S bioavailability in tissue and plasma.
  • The microbiota alters cystathionine γ-lyase activity and cysteine bioavailability.
Update 15. juni 2014: Problems with measurement of H2S: Controversies and Conundrums in Hydrogen Sulfide Biology

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