Hydroxymethyl - methylglutaryl - CoA-lyase (HMGCL) is a key enzyme in ketone body formation.
Expression of the protein HMGCL has been found upregulated in ME (2).
The gene HMGCL has been found epigenetic changed (hypermethylated) in ME (3).
- Fluge et al: Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy / chronic fatigue syndrome. JCI Insight. 2016; 1(21):e89376. Doi 10.1172/jci.insight.89276
- Ciregia et al.
Translational Psychiatry (2016), 6, e904
- Vega et al. DNA methylation Modifications associated with CFS. Plos One, aug 2014, vol 9, Issue 8, e104757