HMGCL and ME

Fluge, Mella et al. have shown that ME is associated with defective oxidative metabolism - most likely involving impaired pyruvate dehydrogenase function - leading to increased utilization  of ketogenic amino acids (1).

Hydroxymethyl - methylglutaryl - CoA-lyase (HMGCL) is a key enzyme in ketone body formation.

Expression of the protein HMGCL has been found upregulated in ME (2).

The gene HMGCL has been found epigenetic changed (hypermethylated) in ME (3).

Reference:

1.  Fluge et al: Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy / chronic fatigue syndrome. JCI Insight. 2016; 1(21):e89376. Doi 10.1172/jci.insight.89276
2. Ciregia et al.
   Translational Psychiatry (2016), 6, e904
   doi:10.1038/tp.2016.184
3. Vega et al. DNA methylation Modifications associated with CFS. Plos One, aug 2014, vol 9, Issue 8, e104757