Pyrroline-5-carboxylic acid is increased in ME patients (2).
The gene ALDH4A1 has been found epigenetic changed (hypermethylated) in ME (3).
Expression of the proteins P5C-dehyrogenase and P5C-synthase have been found upregulated in ME (4).
P5C-dehydrogenase has been found to be an immunoreactive protein against IgGs from POTS-patients (5).
- Wikipedia: Aldehyde dehydrogenase 4 family, member A1
- Naviaux et al: Metabolic features of CFS. www.pnas.org/cgi/doi/10.1073/pnas.1607571113
- Vega et al. DNA methylation Modifications associated with CFS. Plos One, aug 2014, vol 9, Issue 8, e10475
- Ciregia et al.
Translational Psychiatry (2016), 6, e904
- Wang et al: Autoimmunoreactive IgGs from patients with POTS. Prot. Clin. Appl. 2012, 6, 1-11.