The enzyme diacylglycerol kinase zeta (DGKZ) catalyzes diacylglycerol (DAG) to phosphatidic acid (PA).
DGKZ controls DAG metabolism at the immonological synapse between the T cell and a target cell.
Disruption of DAG metabolism impairs the induction of T cell anergy, which is a process important to maintain peripheral T cell totelance.
DGKZ deficiency is associated with enhanced T cell response (2).
- Vega et al: Epigenetic modifications and glucocorticoid sensitivity in ME/CFS. BMC Medical Genomics, 2017, 10, 11
- Gharbi et al: DGKZ controls diacylglycerol metabolism at the immunological synapse. Mol Biol Cell, 2011, 22, 15.