Glycero-3-phosphate has been found up-regulated in ME (3).
The gene GPD2 codes mithochondrial glycerol-3-phosphate dehydrogenase (mGPDH).
mGPDH oxidizes glycerol-3-phosphate to dihydroxyacetone phosphate.
mGPDH is a very important enzyme of intermediary metabolism and as a component of glycerophosphate shuttle at the crossroads of glycolysis, oxidative phosphorylation and fatty acid metabolism (4).
These genes have been found epigenetic changed (hypermethylated) in ME (5):
- GPD2, glycerol-3-phosphate dehydrogenase 2
- SLC37A3, solute carrier family 37, glycerol-3-phosphate transporter
- DAK, dihydroxyacetone kinase 2 homolog
- Fluge et al: Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy / chronic fatigue syndrome. JCI Insight. 2016; 1(21):e89376. Doi 10.1172/jci.insight.89276
- Naviaux et al: Metabolic features of CFS. www.pnas.org/cgi/doi/10.1073/pnas.1607571113
- Germain et al: Metabolic profiling of a ME/CFS discovery cohort reveals disturbances in fatty acid and lipid metabolism. Mol. BioSyst. 2017, 13, 371
- Mracek et al: The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissue. Biochimica et Biophysica Acta 1827, 2013, 401-410.
- Vega et al. DNA methylation Modifications associated with CFS. Plos One, aug 2014, vol 9, Issue 8, e104757