lørdag den 14. december 2013

Caveolae, endothelium and NO production

The Research Council of Norway has this presentation from Øystein Fluge and Olav Mella:

B-lymfocytt deplesjon og sykdomsmekanismer ved kronisk utmattelsessyndrom/ myalgisk encephalopati (ME/CFS)

It is in Norwegian, but page 26 and 28 are in English. 

The hypothesis is about endothelial dysfunction in ME/CFS, and as you can see from page 28 nitric oxide (NO) production in the caveolae is of relevance. 

I have written about Endothelial dysfunction in ME/CFS – and cytochrome CYP2C9, but to find out what is the disease mechanism in ME/CFS, I think we have to learn more about what is going on in the caveolae. Therefore I have searched for some articles about the caveolae and NO production. So, this is not about ME/CFS - this is basic knowledge about caveolae, nitric oxide and nitric oxide synthesis:

Regulation of eNOS in caveolae from: Nitric oxide signaling specificity — the heart of the problem

Caveolins and the regulation of endothelial nitric oxide synthase in the heart

Nitric oxide synthases: regulation and function

Model for TRPC5-mediated feedback of Ca2+ and NO signaling in endothelial cells and attenuation of Ca2+ entry through TRPC6 by NO in smooth muscle cells

And we also need to look into the connection between nitric oxide and the mitochondria: 
Nitric oxide in skeletal muscle: role on mitochondrial biogenesis and function

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