Er Myalgisk Encephalomyelitis en TRP ionkanalopati?

Et stigende antal artikler peger på dysregulering af calcium ion signalering hos ME patienter. Dette involverer Transient Receptor Potential (TRP) ion kanal dysfunktion (Reference 1 og referencer i denne artikel).

Senest har forskere fra Griffith Universitet påvist dysregulering af TRPM7 i NK celler fra ME patienter. Forskningsgruppen har tidligere påvist dysregulering af TRPM3 og skriver i deres nye artikel:

"Findings from this investigation suggest that TRPM7-dependent Ca2+ influx is reduced with agonism and increased with antagonism in ME/CFS patients relative to the age- and sex-matched HCs. The outcomes reported here potentially reflect TRPM3 dysfunction identified in this condition suggesting that ME/CFS is a TRP ion channelopathy."

TRPM7 er en ionkanal, der er involveret i regulering af flere forskellige immun celler (2).

F.eks. regulerer TRPM7 proliferation og polarisering af makrofager (3). Og TRPM7 kinase aktivitet regulerer degranulering af mastceller hos mus (4).

TRP ion kanaler er også dysregulerede i ME komorbiditeten Multiple Chemical Sensitivity (MCS):

Biokemisk forklaring på Multiple Chemical Sensitivity

http://followmeindenmark.blogspot.com/2023/07/biokemisk-forklaring-pa-multiple.html

Referencer

1) Du Preez, S.; Eaton-Fitch, N.; Smith, P.K.; Marshall-Gradisnik, S. Altered TRPM7-Dependent Calcium Influx in Natural Killer Cells of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients. Biomolecules 2023, 13, 1039. https://doi.org/10.3390/biom13071039

https://www.mdpi.com/2218-273X/13/7/1039

2) Liang HY, Chen Y, Wei X, Ma GG, Ding J, Lu C, Zhou RP, Hu W. Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases. Immunology. 2022 Jan;165(1):3-21. doi: 10.1111/imm.13420. Epub 2021 Oct 5. PMID: 34558663.

https://onlinelibrary.wiley.com/doi/full/10.1111/imm.13420

3) Schilling T, Miralles F, Eder C. TRPM7 regulates proliferation and polarisation of macrophages. J Cell Sci. 2014 Nov 1;127(Pt 21):4561-6. doi: 10.1242/jcs.151068. Epub 2014 Sep 9. PMID: 25205764; PMCID: PMC4215710.

https://pubmed.ncbi.nlm.nih.gov/25205764/

4) Zierler S, Sumoza-Toledo A, Suzuki S, Dúill FÓ, Ryazanova LV, Penner R, Ryazanov AG, Fleig A. TRPM7 kinase activity regulates murine mast cell degranulation. J Physiol. 2016 Jun 1;594(11):2957-70. doi: 10.1113/JP271564. Epub 2016 Jan 27. PMID: 26660477; PMCID: PMC4887679.

https://pubmed.ncbi.nlm.nih.gov/26660477/

Biokemisk forklaring på Multiple Chemical Sensitivity

Med over 600 referencer er artiklen "Multiple Chemical Sensitivity: It's time to catch up to the science" en meget grundig gennemgang af den mulige biokemi bag Multiple Chemical Sensitivity (MCS). 

Highlights fra artiklen:

• Functional imaging studies demonstrated multiple brain changes in MCS.
• These brain regions express TRPV1 and TRPA1 receptors.
• TRPV1 and TRPA1 receptors are sensitized in MCS.
• Similar brain regions are involved in comorbid physical and psychological conditions.
• TRP receptor hypersensitivity may contribute to comorbidity in MCS.

Reference: Molot J, Sears M, Anisman H. Multiple chemical sensitivity: It's time to catch up to the science. Neurosci Biobehav Rev. 2023 Aug;151:105227. doi: 10.1016/j.neubiorev.2023.105227. Epub 2023 May 10. PMID: 37172924.

https://www.sciencedirect.com/science/article/pii/S0149763423001963

Tidligere blogindlæg om MCS og TRPA1: 

Transient Receptor Potential in Multiple Chemical Sensitivity

http://followmeindenmark.blogspot.com/2013/02/transient-receptor-potential-in.html

Multiple Chemical Sensitivity, TRPA1 og aktivering af det autonome nervesystem og immunforsvaret

http://followmeindenmark.blogspot.com/2014/08/multiple-chemical-sensitivity-trpa1-og.html

A role for TRPs in ME/CFS/POTS/MCS/pain/endothelial dysfunction...?

http://followmeindenmark.blogspot.com/2014/02/a-role-for-trps-in-mecfspotsmcspainendo.html